2-methyl-5-nitroimidazole
Amakuru y'ibanze:
Izina ryimiti: 2-methyl-5-nitroimidazole;
Izina ry'icyongereza: 2-Methyl-5-nitroimidazole;
Numero ya CAS: 88054-22-2
Inzira ya molekulari: C4H5N3O2
Uburemere bwa molekile: 127.1
EINECS nimero: 618-108-7
Inzira yuburyo:
Ibyiciro bifitanye isano: ibikoresho fatizo; Abahuza imiti; Ibikoresho bya farumasi.
Ubucucike: 1.4 ± 0.1g / cm3
Ingingo yo guteka: 399.5 ± 15.0 ° C kuri 760 mmHg
Ingingo yo gushonga: 252-254ºC
Ingingo yerekana: 195.4 ± 20.4 ° C.
Misa isobanutse: 127.038177
PSA: 74.50000 LogP: -0.10
Kugaragara: Kirisiti yera
Umuvuduko wumwuka: 0.0 ± 0,9 mmHg kuri 25 ° C.
Igipimo cyangiritse: 1.592
Imiterere yububiko: ifunze ahantu hakonje kandi humye ya 0-6 ºC
Igihagararo: ntizishobora kubora iyo ikoreshejwe kandi ibitswe ukurikije amabwiriza.
| Ibisobanuro | igice | bisanzwe |
| Kugaragara | Nka poro yera cyangwa umuhondo | |
| Ibirimo | % | ≥99% |
| Ubushuhe | % | ≤0.3 |
| Sulfate | % | ≤0.3 |
Ahanini ikoreshwa muri synthesis ya metronidazole, dimetazole nibindi biyobyabwenge.
Biboneka na nitrasi ya 2-methylimidazole. Shira aside sulfurike, 2-methylimidazole na sodium sulfate mu nkono ya reaction, koga kandi ushushe, ongeramo aside nitric kuri 150-160 ℃, ongeraho, ukurikize isanduku yisaha kumasaha 1. Kuraho ubushyuhe kuri 140 ℃ munsi, nyuma yo kongeramo amazi namazi ya amoniya kugirango uhindure pH kuri 3.5-4, kristu. Shyira, ukarabe utabogamye, wumye, 2-methyl-5-nitroimidazole.
25k igikapo cyimpapuro cyangwa igikapu (58 × 110) cyometseho umufuka wa pulasitike, umufuka wa kontineri 250 kg (100 × 80); Ukurikije ibyo umukiriya asabwa;
Ububiko bufunze, bubitswe mububiko bukonje, bwijimye, bwumye, kubika no gutwara bigomba kuba byoroshye, kugirango birinde kwangirika nubushuhe, bibujijwe rwose nibiyobyabwenge bivanze.
Uburyo bwo kubyaza umusaruro: Kubona nitrasi ya 2-methylimidazole. Shira aside sulfurike, 2-methylimidazole na sodium sulfate mu nkono ya reaction, koga kandi ushushe, ongeramo aside nitric kuri 150-160 ℃, ongeraho, ukurikize isanduku yisaha kumasaha 1. Kuraho ubushyuhe kuri 140 ℃ munsi, nyuma yo kongeramo amazi namazi ya amoniya kugirango uhindure pH kuri 3.5-4, kristu. Shyira, kwoza utabogamye, wumye, 2-methyl-5-nitroimidazole.
