Ibisabwa byingenzi bya Nucleosides

Intangiriro

Nucleosides, ibice byubaka acide nucleic (ADN na RNA), bigira uruhare rwibanze mubinyabuzima byose. Muguhindura iyi molekile, abahanga bafunguye umurongo munini wibishobora gusaba mubushakashatsi nubuvuzi. Muri iki kiganiro, tuzasesengura bimwe mubisabwaIcleosides.

Uruhare rwa nucleosides yahinduwe

Icleosides yahinduwe ikorwa muguhindura imiterere ya nucleside karemano, nka Adesesine, Guanosine, Cytidine, na Uridine. Izi mpinduka zishobora kuba zirimo impinduka zifatizo, isukari, cyangwa byombi. Imiterere yahinduwe irashobora gutanga ibintu bishya kuri nucleo yahinduwe, bigatuma bikwiranye na porogaramu zitandukanye.

Ibyingenzi

Ivumburwa ry'ibiyobyabwenge:

Abakozi bashinzwe kurwanya: nucleosides yahinduwe mugutegura ibiyobyabwenge bitandukanye. Kurugero, barashobora gukorerwa kugirango ibuza synhesis ya ADN cyangwa kwibanda kuri kanseri yihariye ya kanseri.

Abakozi barwanya Antiveral: Icleoside yahinduwe ikoreshwa mugushiraho imiti igabanya ubukana ishobora kubuza ingwate. Urugero ruzwi cyane ni ugukoresha nucleosite yahinduwe muri Coviccines inkingi ya Covid-19h.

Abakozi ba antibacteri: Kumenyekana nucleosides nayo yerekanye amasezerano mugutezimbere antibiyotike nshya.

Ubwubatsi bwa genetike:

Inkingo za Mrna: NUCLESIDS ni ibintu by'ingenzi bigize inkingo za MRNE, kuko zishobora kuzamura umutekano n'ubudahumuro bya MRNA.

Antissense olivanucleited: Iyi molekile, yagenewe guhambira kuri Mhna Urukurikirane rwa Mhna, rushobora guhindurwa kugirango utezimbere umutekano kandi wihariye.

Ubuvuzi bwa Gene: Kumenyekana kwa Nucleosides birashobora gukoreshwa muguhindura olinetucleotide ya ROPONICLEIDE kuri leta ya leta ya gene, nko gukosora inenge.

Ibikoresho by'ubushakashatsi:

Ibikorwa bya Acicleic Ibibazo: Kuraho nucleosides irashobora kwinjizwa mubuhanga nka fluorescence muri sbriditisation (amafi) hamwe nisesengura rya mikoro.

Aptamers: Acide imwe ya kirimbuzi irashobora guhindurwa kugirango ibone intego zihariye, nka poroteyine cyangwa molekile nto, kandi ifite ibyifuzo mubipima na Therapeutics.

Inyungu za Nucleosides yahinduwe

Guhagarara neza: Ucleoside yahinduwe irashobora kuzamura umutekano wa aside iricleike, bikaba bahanganye no gutesha agaciro imiteguro na enzymes.

Kongera umwihariko: Guhindura birashobora kunoza umwihariko wimikoranire ya acide nucleic, bigatuma intego zifatika za molekile yihariye.

Yongerewe uptake ya selile: nucleoside yahinduwe irashobora kuba igamije kunoza uptake yabo ya selile, yongera imikorere yabo mubikorwa byatangaga.

Umwanzuro

Icleosides yahinduwe yahinduye imirima itandukanye, uko ivumburwa n'ibiyobyabwenge kugera kubuhanga bwa genetike. Ibisobanuro byabo nubushobozi bwo guhuza ibyifuzo byihariye bibamo ibikoresho bitagereranywa kubashakashatsi nabaganga. Mugihe dusobanukiwe na acide ya acide nucleic akomeje kwiyongera, turashobora kwitega kubona naruclesitive ishyari yahinduwe mugihe cyahinduwe mugihe kizaza.